Auto-saving is disabled in this mode, enemies and items are in different areas, and ammo and other items are significantly more scarce. In this mode, enemies deal even more damage than in Nightmare and are even harder to kill.
You cannot change the difficulty in a Nightmare playthrough. Enemies and items are placed in different areas throughout the game. In this mode, enemies deal significantly more damage and are way harder to kill. Nightmare: This mode is unlocked after completing the game on Hardcore.
You cannot change the difficulty in a Hardcore playthrough. Aim Assist will be on, zombies will be weaker and you'll automatically recover a portion of your health as time goes by.